MicroRNA (miRNA) is known to as a vital control mechanism. Each miRNA can control hundreds of messenger RNAs (mRNA), and a mRNA is most often under the control of several miRNAs, resulting in a finely balanced, intricate network of control.
Gaining insight into small RNA expression signature in cells, tissue and biofluid of interest can have great impact on biomarker discovery, detection of treatment targets and insight into mechanisms involved.
While each project is unique and consequently the optimal solution varies accoring to the settings, some elements are will the be fairly consistent across most experiements.
Additional Bioinformatic Analysis for small RNA sequencing